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Crystal structure of streptococcus pyogenes CAS2 at pH 5.6

Analyse Crystal structure of streptococcus pyogenes CAS2 at pH 5.6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4QR0
Type: protein
Length: 165 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CRISPR-associated endoribonuclease CAS2
EC: 3.1.-.-
UniProt: Q99YS8
Pockets: 1 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CRISPR-associated endoribonuclease CAS2 (EC 3.1.-.-)	protein	83	37% helix, 31% strand	Q99YS8
B	CRISPR-associated endoribonuclease CAS2 (EC 3.1.-.-)	protein	82	39% helix, 33% strand	Q99YS8

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	130	0.60	0.85	25	empty

Interfaces

1 interface between chains.

A–B · 1520 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

4QR0 · Crystal structure of Streptococcus pyogenes Cas2 at pH 5.6 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99YS8
Elsewhere: RCSB PDB 4QR0 · PDBe 4QR0 · UniProt Q99YS8

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