Research workbench
Structural basis for the assembly of the sxl-unr translation regulatory complex
Analyse Structural basis for the assembly of the sxl-unr translation regulatory complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4QQB
- Type
- protein + RNA
- Length
- 516 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MSL2 mRNA; Protein sex-lethal; Upstream of N-RAS, isoform a
- UniProt
- P19339, Q9VSK3
- Pockets
- 7 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| P, C | MSL2 mRNA | rna | 17 | — | — |
| A, B | Protein sex-lethal | protein | 169 | 24% helix, 33% strand | P19339 |
| X, Y | Upstream of N-RAS, isoform a | protein | 72 | 4% helix, 50% strand | Q9VSK3 |
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1021 | 0.72 | 0.76 | 79 | empty |
| 2 | 180 | 0.48 | 0.76 | 23 | empty |
| 3 | 213 | 0.47 | 0.75 | 26 | empty |
| 4 | 69 | 0.36 | 0.77 | 17 | empty |
| 5 | 90 | 0.35 | 0.75 | 24 | empty |
Interfaces
8 interfaces between chains.
- P–A · 1961 Ų buried · 44 hydrogen bonds · protein-nucleic
- C–B · 1940 Ų buried · 36 hydrogen bonds · protein-nucleic
- P–X · 608 Ų buried · 14 hydrogen bonds · protein-nucleic
- C–Y · 573 Ų buried · 12 hydrogen bonds · protein-nucleic
- A–B · 470 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4QQB · Structural basis for the assembly of the SXL-UNR translation regulatory complex · the same entry in another collection · chain C against C, TM-score 1.00
- P19339 · AlphaFold monomer V2.0 prediction for protein sex-lethal (P19339) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19339
- Every structure of UniProt Q9VSK3
- Elsewhere: RCSB PDB 4QQB · PDBe 4QQB · UniProt P19339 · UniProt Q9VSK3
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