Research workbench

Crystal structure of human envoplakin plakin repeat domain

Analyse Crystal structure of human envoplakin plakin repeat domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4QMD
Type: protein
Length: 386 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Envoplakin
UniProt: Q92817
Pockets: 5 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Envoplakin	protein	193	44% helix, 15% strand	Q92817

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	516	0.74	0.82	58	empty
2	82	0.57	0.87	21	empty
3	105	0.52	0.82	25	empty
4	100	0.37	0.75	20	empty
5	54	0.32	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 659 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4QMD · Crystal structure of human envoplakin plakin repeat domain · the same entry in another collection · chain A against A, TM-score 1.00
Q92817 · AlphaFold monomer V2.0 prediction for envoplakin (Q92817) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q92817
Elsewhere: RCSB PDB 4QMD · PDBe 4QMD · UniProt Q92817

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.