Research workbench
Atomic structure of tuberculosis necrotizing toxin (tnt) complexed with its immunity factor ift
Analyse Atomic structure of tuberculosis necrotizing toxin (tnt) complexed with its… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4QLP
- Type
- protein
- Length
- 374 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunity factor ift; Alanine and proline rich protein, tuberculosis necrotizing toxin…
- UniProt
- O05443, O05442
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Immunity factor ift | protein | 175 | 35% helix, 29% strand | O05443 |
| B | Alanine and proline rich protein, tuberculosis necrotizing toxin (tnt) | protein | 199 | 20% helix, 22% strand | O05442 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 231 | 0.66 | 0.84 | 54 | empty |
| 2 | 292 | 0.61 | 0.79 | 27 | empty |
| 3 | 68 | 0.36 | 0.78 | 16 | empty |
| 4 | 99 | 0.36 | 0.74 | 20 | empty |
| 5 | 65 | 0.31 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1845 Ų buried · 47 hydrogen bonds · protein-protein
Compared structures
- 4QLP · Atomic structure of tuberculosis necrotizing toxin (TNT) complexed with its immunity… · the same entry in another collection · chain A against A, TM-score 1.00
- O05443 · AlphaFold monomer V2.0 prediction for immunity factor for tnt (O05443) · a predicted model of the same protein · chain A against A, TM-score 0.97
- O05442 · AlphaFold monomer V2.0 prediction for outer membrane channel protein cpnt (O05442) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O05443
- Every structure of UniProt O05442
- Elsewhere: RCSB PDB 4QLP · PDBe 4QLP · UniProt O05443 · UniProt O05442
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