Research workbench
Crystal structure of metabotropic glutamate receptor subtype 1 complexed with glutamate and gadolinium ion
Analyse Crystal structure of metabotropic glutamate receptor subtype 1 complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1ISR
- Type
- protein
- Length
- 448 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor subtype 1
- UniProt
- P23385
- Ligands
- GLU, GD
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metabotropic glutamate receptor subtype 1 | protein | 448 | 35% helix, 20% strand | P23385 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 507 | 0.69 | 0.79 | 60 | GLU |
| 2 | 58 | 0.56 | 0.89 | 18 | empty |
| 3 | 120 | 0.42 | 0.77 | 15 | empty |
| 4 | 97 | 0.39 | 0.77 | 17 | empty |
| 5 | 78 | 0.37 | 0.76 | 20 | empty |
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1ISR · Crystal Structure of Metabotropic Glutamate Receptor Subtype 1 Complexed with Glutamate… · the same entry in another collection · chain A against A, TM-score 1.00
- P23385 · AlphaFold monomer V2.0 prediction for metabotropic glutamate receptor 1 (P23385) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23385
- Elsewhere: RCSB PDB 1ISR · PDBe 1ISR · UniProt P23385
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