Research workbench
I2 (unbound) from CH103 lineage
Analyse I2 (unbound) from CH103 lineage in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4QHN
- Type
- protein
- Length
- 430 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- I2 heavy chain; I2 light chain
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | I2 heavy chain | protein | 222 | 4% helix, 50% strand | — |
| B | I2 light chain | protein | 208 | 7% helix, 48% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 702 | 0.65 | 0.74 | 67 | empty |
| 2 | 108 | 0.49 | 0.81 | 19 | empty |
| 3 | 63 | 0.32 | 0.75 | 20 | empty |
| 4 | 66 | 0.28 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1941 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 4QHN · I2 (unbound) from CH103 Lineage · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4QHN · PDBe 4QHN
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