Research workbench
Structure of the human sjogren larsson syndrome enzyme fatty aldehyde dehydrogenase (faldh)
Analyse Structure of the human sjogren larsson syndrome enzyme fatty aldehyde… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4QGK
- Type
- protein
- Length
- 919 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fatty aldehyde dehydrogenase
- EC
- 1.2.1.3
- UniProt
- P51648
- Pockets
- 6 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fatty aldehyde dehydrogenase (EC 1.2.1.3) | protein | 461 | 47% helix, 17% strand | P51648 |
| B | Fatty aldehyde dehydrogenase (EC 1.2.1.3) | protein | 458 | 47% helix, 17% strand | P51648 |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1026 | 0.84 | 0.84 | 117 | empty |
| 2 | 702 | 0.82 | 0.86 | 70 | empty |
| 3 | 1116 | 0.82 | 0.83 | 97 | empty |
| 4 | 373 | 0.64 | 0.79 | 47 | empty |
| 5 | 185 | 0.52 | 0.79 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 4631 Ų buried · 68 hydrogen bonds · protein-protein
Compared structures
- 4QGK · Structure of the Human Sjogren Larsson Syndrome enzyme fatty aldehyde dehydrogenase… · the same entry in another collection · chain A against A, TM-score 1.00
- P51648 · AlphaFold monomer V2.0 prediction for aldehyde dehydrogenase family 3 member A2 (P51648) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P51648
- Elsewhere: RCSB PDB 4QGK · PDBe 4QGK · UniProt P51648
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