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Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium citrate buffer
Analyse Crystal structure of C117T mutant of human acidic fibroblast growth factor in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4QBV
- Type
- protein
- Length
- 282 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fibroblast growth factor 1
- UniProt
- P05230
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fibroblast growth factor 1 | protein | 141 | 6% helix, 38% strand | P05230 |
Ligands and binding sites
- FLC · Citrate anion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.38 | 0.76 | 21 | empty |
| 2 | 51 | 0.26 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 449 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 4QBV · Crystal structure of C117T mutant of human acidic fibroblast growth factor in sodium… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 4QBV · PDBe 4QBV · UniProt P05230
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