Research workbench
Crystal structure of the plectin 1A actin-binding DOMAIN/INTEGRIN beta 4 fragment complex
Analyse Crystal structure of the plectin 1A actin-binding DOMAIN/INTEGRIN beta 4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Q58
- Type
- protein
- Length
- 825 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Plectin; Integrin beta-4
- UniProt
- Q15149, P16144
- Pockets
- 10 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 30% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Plectin | protein | 225 | 55% helix, 0% strand | Q15149 |
| B | Plectin | protein | 223 | 57% helix, 0% strand | Q15149 |
| C | Integrin beta-4 | protein | 183 | 0% helix, 44% strand | P16144 |
| D | Integrin beta-4 | protein | 194 | 0% helix, 43% strand | P16144 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 812 | 0.68 | 0.75 | 101 | empty |
| 2 | 703 | 0.66 | 0.75 | 57 | empty |
| 3 | 63 | 0.54 | 0.88 | 25 | empty |
| 4 | 142 | 0.51 | 0.79 | 32 | empty |
| 5 | 194 | 0.50 | 0.77 | 21 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1411 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 761 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 443 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 57 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4Q58 · Crystal structure of the plectin 1a actin-binding domain/integrin beta 4 fragment complex · the same entry in another collection · chain A against A, TM-score 1.00
- P16144 · AlphaFold monomer V2.0 prediction for integrin beta-4 (P16144) · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15149
- Every structure of UniProt P16144
- Elsewhere: RCSB PDB 4Q58 · PDBe 4Q58 · UniProt Q15149 · UniProt P16144
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