Research workbench
Crystal structure of CYCLO(L-leucyl-L-phenylalanyl) synthase
Analyse Crystal structure of CYCLO(L-leucyl-L-phenylalanyl) synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Q24
- Type
- protein
- Length
- 224 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CYCLO(L-leucyl-L-phenylalanyl) synthase
- EC
- 2.3.2.20
- UniProt
- Q8GED7
- Ligands
- XVE
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CYCLO(L-leucyl-L-phenylalanyl) synthase (EC 2.3.2.20) | protein | 224 | 58% helix, 15% strand | Q8GED7 |
Ligands and binding sites
- XVE · Phenylmethyl N-[(2S)-4-chloro-3-oxo-1-phenyl-butan-2-yl]carbamate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 340 | 0.75 | 0.86 | 43 | XVE |
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 4Q24 · Crystal structure of Cyclo(L-leucyl-L-phenylalanyl) synthase · the same entry in another collection · chain A against A, TM-score 1.00
- Q8GED7 · AlphaFold monomer V2.0 prediction for CYCLO(L-leucyl-L-phenylalanyl) synthase (Q8GED7) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8GED7
- Elsewhere: RCSB PDB 4Q24 · PDBe 4Q24 · UniProt Q8GED7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.