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Crystal structure of non-neutralizing antibody in complex with epitope II of HCV E2

Analyse Crystal structure of non-neutralizing antibody in complex with epitope II of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4Q0X
Type: protein
Length: 443 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mab 12 heavy chain; Mab 12 light chain; Envelope glycoprotein E2
UniProt: P27958
Pockets: 5 · best druggability 0.46

Structure

x-ray diffraction · 3 distinct chains · 6% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Mab 12 heavy chain	protein	216	6% helix, 54% strand	—
L	Mab 12 light chain	protein	218	4% helix, 50% strand	—
E	Envelope glycoprotein E2	protein	9	56% helix, 0% strand	P27958

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	232	0.46	0.73	43	empty
2	105	0.41	0.77	19	empty
3	141	0.41	0.74	25	empty
4	69	0.31	0.74	15	empty
5	62	0.29	0.74	14	empty

Interfaces

3 interfaces between chains.

H–L · 1816 Å² buried · 14 hydrogen bonds · protein-protein
H–E · 420 Å² buried · 5 hydrogen bonds · protein-protein
L–E · 190 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

4Q0X · Crystal structure of non-neutralizing antibody in complex with Epitope II of HCV E2 · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P27958
Elsewhere: RCSB PDB 4Q0X · PDBe 4Q0X · UniProt P27958

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