Research workbench
Structure of zm ALDH7 in complex with NAD
Analyse Structure of zm ALDH7 in complex with NAD in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PXN
- Type
- protein
- Length
- 996 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- UniProt
- C0PHD8
- Ligands
- NAD
- Pockets
- 3 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Uncharacterized protein | protein | 498 | 39% helix, 23% strand | C0PHD8 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 623 | 0.73 | 0.80 | 81 | NAD |
| 2 | 659 | 0.71 | 0.78 | 86 | NAD |
| 3 | 126 | 0.36 | 0.73 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 869 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4PXN · Structure of Zm ALDH7 in complex with NAD · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C0PHD8
- Elsewhere: RCSB PDB 4PXN · PDBe 4PXN · UniProt C0PHD8
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