Research workbench
Crystal structure of a HLA-B*35:01-hpvg-A4
Analyse Crystal structure of a HLA-B*35:01-hpvg-A4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PRN
- Type
- protein
- Length
- 386 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-35 alpha chain; Beta-2-microglobulin…
- UniProt
- P30685, P61769, Q1HVF7
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-35 alpha chain | protein | 276 | 26% helix, 39% strand | P30685 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C | Epstein-barr nuclear antigen 1 | protein | 11 | 27% helix, 0% strand | Q1HVF7 |
Ligands and binding sites
- ACT · Acetate ion · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 586 | 0.69 | 0.78 | 50 | empty |
| 2 | 89 | 0.42 | 0.79 | 22 | empty |
| 3 | 99 | 0.38 | 0.76 | 21 | empty |
| 4 | 71 | 0.37 | 0.78 | 17 | empty |
| 5 | 59 | 0.33 | 0.77 | 17 | ACT |
Interfaces
2 interfaces between chains.
- A–B · 1354 Ų buried · 25 hydrogen bonds · protein-protein
- A–C · 954 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30685
- Every structure of UniProt P61769
- Every structure of UniProt Q1HVF7
- Elsewhere: RCSB PDB 4PRN · PDBe 4PRN · UniProt P30685 · UniProt P61769 · UniProt Q1HVF7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.