Research workbench
Crystal structure of a HLA-B*35:01-hpvg-D5
Analyse Crystal structure of a HLA-B*35:01-hpvg-D5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PR5
- Type
- protein
- Length
- 386 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-35 alpha chain; Beta-2-microglobulin…
- UniProt
- P30685, P61769, Q3KSS4
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-35 alpha chain | protein | 276 | 27% helix, 39% strand | P30685 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C | Epstein-barr nuclear antigen 1 | protein | 11 | 0% helix, 0% strand | Q3KSS4 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 636 | 0.69 | 0.77 | 57 | empty |
| 2 | 90 | 0.43 | 0.79 | 17 | empty |
| 3 | 86 | 0.43 | 0.79 | 21 | empty |
| 4 | 97 | 0.42 | 0.78 | 24 | empty |
| 5 | 50 | 0.29 | 0.75 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1336 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 950 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30685
- Every structure of UniProt P61769
- Every structure of UniProt Q3KSS4
- Elsewhere: RCSB PDB 4PR5 · PDBe 4PR5 · UniProt P30685 · UniProt P61769 · UniProt Q3KSS4
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