Research workbench
6-phospho-beta-galactosidase form-cst
Analyse 6-phospho-beta-galactosidase form-cst in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4PBG
- Type
- protein
- Length
- 936 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 6-phospho-beta-D-galactosidase
- EC
- 3.2.1.85
- UniProt
- P11546
- Ligands
- BGP
- Pockets
- 7 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 6-phospho-beta-D-galactosidase (EC 3.2.1.85) | protein | 468 | 42% helix, 18% strand | P11546 |
Ligands and binding sites
- BGP · 6-O-phosphono-beta-D-galactopyranose · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 528 | 0.85 | 0.91 | 55 | BGP |
| 2 | 516 | 0.85 | 0.91 | 56 | BGP |
| 3 | 307 | 0.58 | 0.77 | 30 | empty |
| 4 | 335 | 0.57 | 0.76 | 32 | empty |
| 5 | 194 | 0.46 | 0.74 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 535 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11546
- Elsewhere: RCSB PDB 4PBG · PDBe 4PBG · UniProt P11546
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