Research workbench
Crystal structure of loop-swapped interleukin-36RA
Analyse Crystal structure of loop-swapped interleukin-36RA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4P0J
- Type
- protein
- Length
- 294 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-36 receptor ANTAGONIST/INTERLEUKIN-36 gamma chimera protein
- UniProt
- Q9UBH0, Q9NZH8
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 7% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Interleukin-36 receptor ANTAGONIST/INTERLEUKIN-36 gamma chimera protein | protein | 147 | 7% helix, 41% strand | Q9UBH0, Q9NZH8 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 273 | 0.59 | 0.78 | 42 | empty |
| 2 | 111 | 0.56 | 0.84 | 25 | empty |
| 3 | 60 | 0.29 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 784 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4P0J · Crystal Structure of Loop-Swapped Interleukin-36Ra · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UBH0 · AlphaFold monomer V2.0 prediction for interleukin-36 receptor antagonist protein (Q9UBH0) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q9NZH8 · AlphaFold monomer V2.0 prediction for interleukin-36 gamma (Q9NZH8) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UBH0
- Every structure of UniProt Q9NZH8
- Elsewhere: RCSB PDB 4P0J · PDBe 4P0J · UniProt Q9UBH0 · UniProt Q9NZH8
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