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Engineered thermostable dimeric cocaine esterase

Analyse Engineered thermostable dimeric cocaine esterase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4P08
Type: protein
Length: 571 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cocaine esterase
EC: 3.1.1.84
UniProt: Q9L9D7
Pockets: 3 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 24% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cocaine esterase (EC 3.1.1.84)	protein	571	24% helix, 31% strand	Q9L9D7

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	206	0.59	0.80	32	empty
2	85	0.55	0.85	19	empty
3	71	0.52	0.86	29	empty

Compared structures

4P08 · Engineered thermostable dimeric cocaine esterase · the same entry in another collection · chain A against A, TM-score 1.00
Q9L9D7 · AlphaFold monomer V2.0 prediction for cocaine esterase (Q9L9D7) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9L9D7
Elsewhere: RCSB PDB 4P08 · PDBe 4P08 · UniProt Q9L9D7

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