Research workbench
Calcium-free campari V0.2
Analyse Calcium-free campari V0.2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OY4
- Type
- protein
- Length
- 334 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chimera protein of calmodulin, gpf-like protein eosfp, and myosin light chain kinase
- UniProt
- P62161, Q5S6Z9, Q6LDG3
- Ligands
- CR8, SO4
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 22% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chimera protein of calmodulin, gpf-like protein eosfp, and myosin light chain kinase | protein | 334 | 22% helix, 39% strand | P62161, Q5S6Z9, Q6LDG3 |
Ligands and binding sites
- CR8 · 2-[1-amino-2-(1H-imidazol-5-yl)ethyl]-1-(carboxymethyl)-4-[(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-1H-imidazol-5-olate · ligand · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 70 | 0.73 | 0.98 | 20 | CR8 |
| 2 | 459 | 0.68 | 0.79 | 56 | empty |
| 3 | 82 | 0.38 | 0.77 | 17 | empty |
| 4 | 70 | 0.30 | 0.74 | 22 | empty |
Modifications
Observed in the structure: 2 covalent (covalent ligand).
Compared structures
- 4OY4 · calcium-free CaMPARI v0.2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62161
- Every structure of UniProt Q5S6Z9
- Every structure of UniProt Q6LDG3
- Elsewhere: RCSB PDB 4OY4 · PDBe 4OY4 · UniProt P62161 · UniProt Q5S6Z9 · UniProt Q6LDG3
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