Research workbench
Structural basis of SOSS1 complex assembly
Analyse Structural basis of SOSS1 complex assembly in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OWT
- Type
- protein
- Length
- 577 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrator complex subunit 3; Soss complex subunit B1; Soss complex subunit C
- UniProt
- Q68E01, Q9BQ15, Q9NRY2
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrator complex subunit 3 | protein | 466 | 70% helix, 1% strand | Q68E01 |
| B | Soss complex subunit B1 | protein | 72 | 13% helix, 42% strand | Q9BQ15 |
| C | Soss complex subunit C | protein | 39 | 36% helix, 15% strand | Q9NRY2 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.64 | 0.84 | 34 | empty |
| 2 | 543 | 0.64 | 0.76 | 59 | empty |
| 3 | 70 | 0.36 | 0.77 | 16 | empty |
| 4 | 58 | 0.31 | 0.76 | 12 | empty |
| 5 | 63 | 0.30 | 0.74 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–C · 1283 Ų buried · 24 hydrogen bonds · protein-protein
- A–B · 911 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 4OWT · Structural basis of SOSS1 complex assembly · the same entry in another collection · chain A against A, TM-score 1.00
- Q68E01 · AlphaFold monomer V2.0 prediction for integrator complex subunit 3 (Q68E01) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9NRY2 · AlphaFold monomer V2.0 prediction for soss complex subunit C (Q9NRY2) · a predicted model of the same protein · chain C against A, TM-score 0.82
- Q9BQ15 · AlphaFold monomer V2.0 prediction for soss complex subunit B1 (Q9BQ15) · a predicted model of the same protein · chain B against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q68E01
- Every structure of UniProt Q9BQ15
- Every structure of UniProt Q9NRY2
- Elsewhere: RCSB PDB 4OWT · PDBe 4OWT · UniProt Q68E01 · UniProt Q9BQ15 · UniProt Q9NRY2
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