Research workbench
Anti-MT1-mmp monoclonal antibody
Analyse Anti-MT1-mmp monoclonal antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OUU
- Type
- protein
- Length
- 855 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ANTI_MT1-mmp heavy chain; ANTI_MT1-mmp light chain
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 53% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | ANTI_MT1-mmp heavy chain | protein | 211 | 9% helix, 53% strand | — |
| B | ANTI_MT1-mmp heavy chain | protein | 210 | 9% helix, 53% strand | — |
| L, A | ANTI_MT1-mmp light chain | protein | 217 | 6% helix, 52% strand | — |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 738 | 0.78 | 0.82 | 81 | empty |
| 2 | 434 | 0.60 | 0.75 | 56 | empty |
| 3 | 324 | 0.54 | 0.74 | 45 | empty |
| 4 | 58 | 0.48 | 0.85 | 20 | empty |
| 5 | 84 | 0.31 | 0.73 | 17 | empty |
Interfaces
5 interfaces between chains.
- H–L · 1604 Ų buried · 18 hydrogen bonds · protein-protein
- B–A · 1521 Ų buried · 15 hydrogen bonds · protein-protein
- H–B · 293 Ų buried · 4 hydrogen bonds · protein-protein
- H–A · 203 Ų buried · 2 hydrogen bonds · protein-protein
- B–L · 163 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 4OUU · anti-MT1-MMP monoclonal antibody · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4OUU · PDBe 4OUU
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