Research workbench
Crystal structure of the C-terminal regulatory domain of murine GCN2
Analyse Crystal structure of the C-terminal regulatory domain of murine GCN2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OTN
- Type
- protein
- Length
- 242 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 2-alpha kinase 4
- EC
- 2.7.11.1
- UniProt
- Q9QZ05
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) | protein | 123 | 47% helix, 22% strand | Q9QZ05 |
| B | Eukaryotic translation initiation factor 2-alpha kinase 4 (EC 2.7.11.1) | protein | 119 | 50% helix, 23% strand | Q9QZ05 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A
- EDO · 1,2-ethanediol · additive · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.46 | 0.76 | 21 | EDO |
| 2 | 75 | 0.42 | 0.80 | 18 | empty |
| 3 | 131 | 0.39 | 0.73 | 19 | empty |
| 4 | 66 | 0.30 | 0.74 | 12 | EDO |
Interfaces
1 interface between chains.
- A–B · 2176 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 4OTN · Crystal structure of the C-terminal regulatory domain of murine GCN2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9QZ05 · AlphaFold monomer V2.0 prediction for eif-2-alpha kinase GCN2 (Q9QZ05) · a predicted model of the same protein · chain B against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9QZ05
- Elsewhere: RCSB PDB 4OTN · PDBe 4OTN · UniProt Q9QZ05
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.