Research workbench
Crystal structure of TLE1 N-terminal Q-domain residues 1-156
Analyse Crystal structure of TLE1 N-terminal Q-domain residues 1-156 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OM2
- Type
- protein
- Length
- 437 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transducin-like enhancer protein 1
- UniProt
- Q04724
- Pockets
- 1 · best druggability 0.60
Structure
x-ray diffraction · 4 distinct chains · 88% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transducin-like enhancer protein 1 | protein | 112 | 87% helix, 0% strand | Q04724 |
| B | Transducin-like enhancer protein 1 | protein | 107 | 88% helix, 0% strand | Q04724 |
| C | Transducin-like enhancer protein 1 | protein | 110 | 88% helix, 0% strand | Q04724 |
| D | Transducin-like enhancer protein 1 | protein | 108 | 89% helix, 0% strand | Q04724 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.60 | 0.85 | 27 | empty |
Interfaces
6 interfaces between chains.
- A–C · 2668 Ų buried · 12 hydrogen bonds · protein-protein
- B–D · 2645 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 393 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 387 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 291 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4OM2 · Crystal structure of TLE1 N-terminal Q-domain residues 1-156 · the same entry in another collection · chain D against D, TM-score 1.00
- Q04724 · AlphaFold monomer V2.0 prediction for transducin-like enhancer protein 1 (Q04724) · a predicted model of the same protein · chain B against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04724
- Elsewhere: RCSB PDB 4OM2 · PDBe 4OM2 · UniProt Q04724
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