Research workbench
Ancestral steroid receptor 1 in complex with estrogen response element DNA
Analyse Ancestral steroid receptor 1 in complex with estrogen response element DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OLN
- Type
- protein + DNA
- Length
- 175 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ANCSR1; 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*GP *a)-3'…
- Ligands
- ZN, NA
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 32% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ANCSR1 | protein | 70 | 34% helix, 14% strand | — |
| B | ANCSR1 | protein | 67 | 30% helix, 12% strand | — |
| E | 5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*GP*AP*GP*TP*GP*AP*CP*CP*TP*GP *a)-3' | dna | 19 | — | — |
| F | 5'-D(*TP*CP*AP*GP*GP*TP*CP*AP*CP*TP*CP*TP*GP*AP*CP*CP*TP*GP *G)-3' | dna | 19 | — | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 595 | 0.69 | 0.78 | 52 | empty |
| 2 | 81 | 0.32 | 0.74 | 18 | empty |
Interfaces
6 interfaces between chains.
- E–F · 858 Ų buried · 81 hydrogen bonds · nucleic-nucleic
- A–B · 426 Ų buried · 5 hydrogen bonds · protein-protein
- B–E · 397 Ų buried · 10 hydrogen bonds · protein-nucleic
- A–F · 363 Ų buried · 8 hydrogen bonds · protein-nucleic
- A–E · 318 Ų buried · 7 hydrogen bonds · protein-nucleic
Compared structures
- 4OLN · Ancestral Steroid Receptor 1 in complex with estrogen response element DNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 4OLN · PDBe 4OLN
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