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Crystal structure of G3-519, an anti-HIV monoclonal antibody

Analyse Crystal structure of G3-519, an anti-HIV monoclonal antibody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1IL1
Type: protein
Length: 438 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Monoclonal antibody G3-519 (heavy chain); Monoclonal antibody G3-519 (light chain)
Pockets: 4 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Monoclonal antibody G3-519 (heavy chain)	protein	219	7% helix, 51% strand	—
B	Monoclonal antibody G3-519 (light chain)	protein	219	6% helix, 53% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	706	0.65	0.74	55	empty
2	179	0.52	0.78	29	empty
3	155	0.48	0.77	28	empty
4	93	0.37	0.75	21	empty

Interfaces

1 interface between chains.

A–B · 1827 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1IL1 · Crystal structure of G3-519, an anti-HIV monoclonal antibody · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1IL1 · PDBe 1IL1

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