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Crystal structure of succinic semialdehyde dehydrogenase from streptococcus pyogenes in complex with NADP+ as the cofactor

Analyse Crystal structure of succinic semialdehyde dehydrogenase from streptococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4OGD
Type: protein
Length: 910 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Succinate-semialdehyde dehydrogenase
UniProt: H8HE26
Pockets: 8 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Succinate-semialdehyde dehydrogenase	protein	455	44% helix, 20% strand	H8HE26

Pockets

8 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	563	0.74	0.81	50	empty
2	479	0.70	0.80	59	empty
3	201	0.67	0.85	35	empty
4	422	0.64	0.78	47	empty
5	434	0.63	0.77	44	empty

Interfaces

1 interface between chains.

A–B · 2664 Å² buried · 36 hydrogen bonds · protein-protein

Compared structures

4OGD · Crystal structure of succinic semialdehyde dehydrogenase from Streptococcus pyogenes in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt H8HE26
Elsewhere: RCSB PDB 4OGD · PDBe 4OGD · UniProt H8HE26

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