Research workbench
Crystal structure of apo carboxy cgmp binding domain of plasmodium falciparum pkg
Analyse Crystal structure of apo carboxy cgmp binding domain of plasmodium falciparum… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4OFF
- Type
- protein
- Length
- 124 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cgmp-dependent protein kinase
- EC
- 2.7.11.12
- UniProt
- Q8MMZ4
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.41
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cgmp-dependent protein kinase (EC 2.7.11.12) | protein | 124 | 31% helix, 33% strand | Q8MMZ4 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.41 | 0.77 | 19 | SO4 |
| 2 | 88 | 0.34 | 0.74 | 14 | empty |
Compared structures
- 4OFF · Crystal structure of apo carboxy cGMP binding domain of Plasmodium falciparum PKG · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8MMZ4
- Elsewhere: RCSB PDB 4OFF · PDBe 4OFF · UniProt Q8MMZ4
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