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Crystal structure of a dog lipocalin allergen

Analyse Crystal structure of a dog lipocalin allergen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4ODD
Type: protein
Length: 450 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipocalin allergen
UniProt: J9P950
Pockets: 8 · best druggability 0.82

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Lipocalin allergen	protein	152	18% helix, 47% strand	J9P950
A, C	Lipocalin allergen	protein	149	15% helix, 48% strand	J9P950

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.82	0.99	22	empty
2	130	0.81	0.98	21	empty
3	123	0.81	0.98	20	empty
4	201	0.60	0.82	29	empty
5	137	0.46	0.77	25	empty

Interfaces

2 interfaces between chains.

A–C · 673 Å² buried · 6 hydrogen bonds · protein-protein
B–A · 506 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

4ODD · Crystal structure of a dog lipocalin allergen · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt J9P950
Elsewhere: RCSB PDB 4ODD · PDBe 4ODD · UniProt J9P950

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