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Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide

Analyse Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4OAJ
Type: protein
Length: 99 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Disks large homolog 1; 5-hydroxytryptamine receptor 2A peptide
UniProt: Q811D0, P14842

Structure

x-ray diffraction · 2 distinct chains · 14% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Disks large homolog 1	protein	92	15% helix, 41% strand	Q811D0
B	5-hydroxytryptamine receptor 2A peptide	protein	7	0% helix, 29% strand	P14842

Interfaces

1 interface between chains.

A–B · 456 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4OAJ · Crystal structure of the complex between SAP97 PDZ2 and 5HT2A receptor peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q811D0 · AlphaFold monomer V2.0 prediction for disks large homolog 1 (Q811D0) · a predicted model of the same protein · chain A against A, TM-score 0.98
P14842 · AlphaFold monomer V2.0 prediction for 5-hydroxytryptamine receptor 2A (P14842) · a predicted model of the same protein · chain B against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q811D0
Every structure of UniProt P14842
Elsewhere: RCSB PDB 4OAJ · PDBe 4OAJ · UniProt Q811D0 · UniProt P14842

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