Research workbench
Mechanism of transhydrogenase coupling proton translocation and hydride transfer
Analyse Mechanism of transhydrogenase coupling proton translocation and hydride transfer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4O9T
- Type
- protein
- Length
- 1,410 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD(P) transhydrogenase subunit alpha 2; NAD(P) transhydrogenase subunit beta
- EC
- 1.6.1.2
- UniProt
- Q72GR9, Q72GS0
- Pockets
- 20 · best druggability 0.60
Structure
x-ray diffraction · 4 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E | NAD(P) transhydrogenase subunit alpha 2 (EC 1.6.1.2) | protein | 94 | 79% helix, 0% strand | Q72GR9 |
| B, F | NAD(P) transhydrogenase subunit beta (EC 1.6.1.2) | protein | 262 | 81% helix, 0% strand | Q72GS0 |
| C, G | NAD(P) transhydrogenase subunit alpha 2 (EC 1.6.1.2) | protein | 89 | 79% helix, 0% strand | Q72GR9 |
| D, H | NAD(P) transhydrogenase subunit beta (EC 1.6.1.2) | protein | 260 | 80% helix, 0% strand | Q72GS0 |
Pockets
20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.60 | 0.80 | 38 | empty |
| 2 | 111 | 0.58 | 0.85 | 22 | empty |
| 3 | 229 | 0.54 | 0.77 | 32 | empty |
| 4 | 208 | 0.52 | 0.77 | 33 | empty |
| 5 | 144 | 0.47 | 0.76 | 19 | empty |
Interfaces
10 interfaces between chains.
- G–H · 3547 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 3545 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 3545 Ų buried · 20 hydrogen bonds · protein-protein
- C–D · 3508 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 585 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4O9T · Mechanism of transhydrogenase coupling proton translocation and hydride transfer · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q72GR9
- Every structure of UniProt Q72GS0
- Elsewhere: RCSB PDB 4O9T · PDBe 4O9T · UniProt Q72GR9 · UniProt Q72GS0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.