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Crystal structure of mycobacterium tuberculosis maltose kinase mak

Analyse Crystal structure of mycobacterium tuberculosis maltose kinase mak in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4O7O
Type: protein
Length: 884 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Maltokinase
EC: 2.7.1.175
UniProt: O07177
Ligands: SO4
Pockets: 16 · best druggability 0.84

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Maltokinase (EC 2.7.1.175)	protein	433	44% helix, 26% strand	O07177
B	Maltokinase (EC 2.7.1.175)	protein	451	43% helix, 25% strand	O07177

Ligands and binding sites

SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	332	0.84	0.94	41	empty
2	342	0.73	0.85	39	empty
3	287	0.72	0.86	34	empty
4	433	0.67	0.79	46	empty
5	57	0.67	0.95	17	empty

Interfaces

1 interface between chains.

A–B · 2702 Å² buried · 50 hydrogen bonds · protein-protein

Compared structures

4O7O · Crystal structure of Mycobacterium tuberculosis maltose kinase MaK · the same entry in another collection · chain B against B, TM-score 1.00
O07177 · AlphaFold monomer V2.0 prediction for maltokinase (O07177) · a predicted model of the same protein · chain B against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O07177
Elsewhere: RCSB PDB 4O7O · PDBe 4O7O · UniProt O07177

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