Research workbench
Crystal structure of SMARCAL1 harp substrate recognition domain
Analyse Crystal structure of SMARCAL1 harp substrate recognition domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4O66
- Type
- protein
- Length
- 274 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a-like…
- EC
- 3.6.4.-
- UniProt
- Q8BJL0
- Ligands
- NA, SO4
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a-like protein 1 (EC 3.6.4.-) | protein | 67 | 30% helix, 39% strand | Q8BJL0 |
| C, D | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily a-like protein 1 (EC 3.6.4.-) | protein | 70 | 29% helix, 37% strand | Q8BJL0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 395 | 0.80 | 0.89 | 51 | SO4 |
| 2 | 83 | 0.33 | 0.73 | 13 | empty |
| 3 | 51 | 0.30 | 0.76 | 15 | empty |
| 4 | 52 | 0.26 | 0.73 | 13 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2015 Ų buried · 38 hydrogen bonds · protein-protein
- A–B · 1737 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 294 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 282 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 47 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4O66 · Crystal Structure of SMARCAL1 HARP substrate recognition domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BJL0 · AlphaFold monomer V2.0 prediction for SWI/SNF-related matrix- associated actin-dependent… · a predicted model of the same protein · chain A against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8BJL0
- Elsewhere: RCSB PDB 4O66 · PDBe 4O66 · UniProt Q8BJL0
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