Research workbench
Crystal structure of alkylhydroperoxide reductase subunit C from E. COLI
Analyse Crystal structure of alkylhydroperoxide reductase subunit C from E. COLI in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4O5R
- Type
- protein
- Length
- 832 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ahpc component, subunit of alkylhydroperoxide reductase
- EC
- 1.8.1.-, 1.11.1.15
- UniProt
- C6EK89
- Pockets
- 15 · best druggability 0.73
Structure
x-ray diffraction · 3 distinct chains · 31% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Ahpc component, subunit of alkylhydroperoxide reductase (EC 1.8.1.-, 1.11.1.15) | protein | 167 | 29% helix, 29% strand | C6EK89 |
| B | Ahpc component, subunit of alkylhydroperoxide reductase (EC 1.8.1.-, 1.11.1.15) | protein | 166 | 30% helix, 28% strand | C6EK89 |
| E | Ahpc component, subunit of alkylhydroperoxide reductase (EC 1.8.1.-, 1.11.1.15) | protein | 165 | 33% helix, 29% strand | C6EK89 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.73 | 0.92 | 22 | empty |
| 2 | 122 | 0.73 | 0.92 | 19 | empty |
| 3 | 163 | 0.54 | 0.80 | 33 | empty |
| 4 | 149 | 0.54 | 0.81 | 31 | empty |
| 5 | 91 | 0.52 | 0.83 | 20 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1318 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1252 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 681 Ų buried · 0 hydrogen bonds · protein-protein
- D–E · 671 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4O5R · Crystal structure of Alkylhydroperoxide Reductase subunit C from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C6EK89
- Elsewhere: RCSB PDB 4O5R · PDBe 4O5R · UniProt C6EK89
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.