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Crystal structure of carbomonoxy murine neuroglobin mutant V140W

Analyse Crystal structure of carbomonoxy murine neuroglobin mutant V140W in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4O2G
Type: protein
Length: 146 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neuroglobin
UniProt: Q9ER97
Ligands: HEM, CMO
Pockets: 1 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neuroglobin	protein	146	79% helix, 1% strand	Q9ER97

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
CMO · Carbon monoxide · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	348	0.76	0.86	30	HEM, CMO

Compared structures

4O2G · Crystal structure of carbomonoxy murine neuroglobin mutant V140W · the same entry in another collection · chain A against A, TM-score 1.00
Q9ER97 · AlphaFold monomer V2.0 prediction for neuroglobin (Q9ER97) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9ER97
Elsewhere: RCSB PDB 4O2G · PDBe 4O2G · UniProt Q9ER97

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