Research workbench

Crystal structure of the regulatory domain of mtbglnr

Analyse Crystal structure of the regulatory domain of mtbglnr in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4O1I
Type: protein
Length: 566 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulatory protein
UniProt: O53830
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, E	Transcriptional regulatory protein	protein	113	35% helix, 22% strand	O53830
D	Transcriptional regulatory protein	protein	114	35% helix, 21% strand	O53830

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	279	0.60	0.79	50	empty
2	120	0.44	0.77	20	empty
3	70	0.36	0.77	20	empty

Interfaces

6 interfaces between chains.

C–D · 774 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 751 Å² buried · 11 hydrogen bonds · protein-protein
B–D · 421 Å² buried · 1 hydrogen bond · protein-protein
C–E · 237 Å² buried · 0 hydrogen bonds · protein-protein
D–E · 111 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4O1I · Crystal Structure of the regulatory domain of MtbGlnR · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O53830
Elsewhere: RCSB PDB 4O1I · PDBe 4O1I · UniProt O53830

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.