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Apo structure of a methyltransferase component involved in O- demethylation

Analyse Apo structure of a methyltransferase component involved in O- demethylation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4O0Q
Type: protein
Length: 541 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dihydropteroate synthase dhps
UniProt: B8FW00
Pockets: 6 · best druggability 0.53

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dihydropteroate synthase dhps	protein	273	49% helix, 15% strand	B8FW00
B	Dihydropteroate synthase dhps	protein	268	51% helix, 15% strand	B8FW00

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	190	0.53	0.78	33	empty
2	242	0.52	0.76	35	empty
3	188	0.46	0.75	22	empty
4	149	0.44	0.75	22	empty
5	93	0.40	0.77	19	empty

Interfaces

1 interface between chains.

A–B · 1515 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

4O0Q · Apo structure of a methyltransferase component involved in O-demethylation · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B8FW00
Elsewhere: RCSB PDB 4O0Q · PDBe 4O0Q · UniProt B8FW00

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