Research workbench
Crystal structure of PF3D7_1475600, a bromodomain from plasmodium falciparum
Analyse Crystal structure of PF3D7_1475600, a bromodomain from plasmodium falciparum in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NXJ
- Type
- protein
- Length
- 352 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain protein
- UniProt
- Q8IK82
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 69% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain protein | protein | 118 | 69% helix, 0% strand | Q8IK82 |
| B, C | Bromodomain protein | protein | 117 | 68% helix, 0% strand | Q8IK82 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 111 | 0.50 | 0.80 | 22 | empty |
| 2 | 110 | 0.49 | 0.80 | 20 | empty |
| 3 | 95 | 0.47 | 0.80 | 18 | empty |
Interfaces
1 interface between chains.
- A–C · 138 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4NXJ · Crystal Structure of PF3D7_1475600, a bromodomain from Plasmodium Falciparum · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IK82
- Elsewhere: RCSB PDB 4NXJ · PDBe 4NXJ · UniProt Q8IK82
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