Research workbench
Crystal structure of the effector-immunity protein complex
Analyse Crystal structure of the effector-immunity protein complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NSO
- Type
- protein
- Length
- 291 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Effector protein; Immunity protein
- UniProt
- Q9KN42, Q9KN41
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Effector protein | protein | 197 | 61% helix, 4% strand | Q9KN42 |
| B | Immunity protein | protein | 94 | 79% helix, 0% strand | Q9KN41 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 272 | 0.69 | 0.84 | 44 | empty |
| 2 | 64 | 0.33 | 0.76 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1219 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 4NSO · Crystal structure of the effector-immunity protein complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9KN41 · AlphaFold monomer V2.0 prediction for antitoxin protein TSIV3 (Q9KN41) · a predicted model of the same protein · chain B against A, TM-score 0.94
- Q9KN42 · AlphaFold monomer V2.0 prediction for type VI secretion system spike protein VGRG3… · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KN42
- Every structure of UniProt Q9KN41
- Elsewhere: RCSB PDB 4NSO · PDBe 4NSO · UniProt Q9KN42 · UniProt Q9KN41
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