Research workbench
Structure of mycobacterium tuberculosis extracytoplasmic function sigma factor sigk in complex with the cytosolic domain of its cognate anti-sigma factor rska
Analyse Structure of mycobacterium tuberculosis extracytoplasmic function sigma factor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NQW
- Type
- protein
- Length
- 221 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ecf RNA polymerase sigma factor sigk; Anti-sigma-K factor rska
- UniProt
- O53730, O53729
- Ligands
- CD
- Pockets
- 1 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ecf RNA polymerase sigma factor sigk | protein | 148 | 80% helix, 0% strand | O53730 |
| B | Anti-sigma-K factor rska | protein | 73 | 77% helix, 0% strand | O53729 |
Ligands and binding sites
- CD · Cadmium ion · metal · 10 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.55 | 0.77 | 25 | CD |
Interfaces
1 interface between chains.
- A–B · 2142 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 4NQW · Structure of Mycobacterium tuberculosis extracytoplasmic function sigma factor SigK in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O53730
- Every structure of UniProt O53729
- Elsewhere: RCSB PDB 4NQW · PDBe 4NQW · UniProt O53730 · UniProt O53729
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