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Crystal structure of asparaginyl endopeptidase (AEP)/LEGUMAIN activated at pH 4.5
Analyse Crystal structure of asparaginyl endopeptidase (AEP)/LEGUMAIN activated at pH… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NOM
- Type
- protein
- Length
- 407 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Legumain
- EC
- 3.4.22.34
- UniProt
- O89017
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Legumain (EC 3.4.22.34) | protein | 407 | 45% helix, 14% strand | O89017 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.53 | 0.83 | 24 | empty |
| 2 | 70 | 0.45 | 0.82 | 17 | empty |
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4NOM · Crystal structure of asparaginyl endopeptidase (AEP)/Legumain activated at pH 4.5 · the same entry in another collection · chain A against A, TM-score 1.00
- O89017 · AlphaFold monomer V2.0 prediction for legumain (O89017) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O89017
- Elsewhere: RCSB PDB 4NOM · PDBe 4NOM · UniProt O89017
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