Research workbench

Subunit PA0372 of heterodimeric zinc protease PA0371-PA0372

Analyse Subunit PA0372 of heterodimeric zinc protease PA0371-PA0372 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4NNZ
Type: protein
Length: 795 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable zinc protease
UniProt: Q9I6C2
Pockets: 9 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 48% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable zinc protease	protein	398	49% helix, 20% strand	Q9I6C2
B	Probable zinc protease	protein	397	47% helix, 20% strand	Q9I6C2

Ligands and binding sites

PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	624	0.69	0.78	92	empty
2	486	0.68	0.79	44	empty
3	457	0.62	0.76	39	empty
4	416	0.61	0.76	39	empty
5	199	0.47	0.75	38	empty

Interfaces

1 interface between chains.

A–B · 1114 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

4NNZ · Subunit PA0372 of heterodimeric zinc protease PA0371-PA0372 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9I6C2
Elsewhere: RCSB PDB 4NNZ · PDBe 4NNZ · UniProt Q9I6C2

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