Research workbench
Crystal structure of apo manganese ABC transporter mntc from staphylococcus aureus bound to an antagonistic Fab fragment
Analyse Crystal structure of apo manganese ABC transporter mntc from staphylococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NNP
- Type
- protein
- Length
- 1,427 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lipoprotein; Heavy chain of antagonistic Fab fragment; Light chain of antagonistic Fab…
- UniProt
- Q99VY4
- Pockets
- 19 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 29% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lipoprotein | protein | 273 | 49% helix, 14% strand | Q99VY4 |
| B | Lipoprotein | protein | 274 | 50% helix, 11% strand | Q99VY4 |
| H, X | Heavy chain of antagonistic Fab fragment | protein | 227 | 3% helix, 50% strand | — |
| L, Y | Light chain of antagonistic Fab fragment | protein | 213 | 6% helix, 51% strand | — |
Pockets
19 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1001 | 0.73 | 0.76 | 80 | empty |
| 2 | 623 | 0.62 | 0.73 | 65 | empty |
| 3 | 380 | 0.61 | 0.77 | 55 | empty |
| 4 | 483 | 0.59 | 0.74 | 57 | empty |
| 5 | 115 | 0.49 | 0.80 | 25 | empty |
Interfaces
8 interfaces between chains.
- H–L · 2107 Ų buried · 20 hydrogen bonds · protein-protein
- X–Y · 2084 Ų buried · 21 hydrogen bonds · protein-protein
- B–X · 634 Ų buried · 8 hydrogen bonds · protein-protein
- A–H · 625 Ų buried · 7 hydrogen bonds · protein-protein
- A–L · 329 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 4NNP · Crystal Structure of Apo Manganese ABC transporter MntC from Staphylococcus aureus bound… · the same entry in another collection · chain Y against Y, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99VY4
- Elsewhere: RCSB PDB 4NNP · PDBe 4NNP · UniProt Q99VY4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.