Research workbench
Protein crystal structure of human borjeson-forssman-lehmann syndrome associated protein PHF6
Analyse Protein crystal structure of human borjeson-forssman-lehmann syndrome… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NN2
- Type
- protein
- Length
- 242 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phd finger protein 6
- UniProt
- Q8IWS0
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phd finger protein 6 | protein | 124 | 26% helix, 19% strand | Q8IWS0 |
| B | Phd finger protein 6 | protein | 118 | 28% helix, 19% strand | Q8IWS0 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 258 | 0.69 | 0.85 | 44 | empty |
| 2 | 52 | 0.26 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 497 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4NN2 · Protein Crystal Structure of Human Borjeson-Forssman-Lehmann Syndrome Associated Protein… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IWS0 · AlphaFold monomer V2.0 prediction for phd finger protein 6 (Q8IWS0) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IWS0
- Elsewhere: RCSB PDB 4NN2 · PDBe 4NN2 · UniProt Q8IWS0
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