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Crystal structure of the catalytic core of RRP6 from trypanosoma brucei, mutant C496S
Analyse Crystal structure of the catalytic core of RRP6 from trypanosoma brucei, mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NLC
- Type
- protein
- Length
- 355 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal RNA processing protein 6
- UniProt
- Q581R8
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribosomal RNA processing protein 6 | protein | 355 | 47% helix, 11% strand | Q581R8 |
Ligands and binding sites
- PEG · Di(hydroxyethyl)ether · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 294 | 0.64 | 0.81 | 32 | PEG |
| 2 | 187 | 0.50 | 0.77 | 26 | empty |
| 3 | 160 | 0.41 | 0.73 | 25 | PEG |
Compared structures
- 4NLC · Crystal structure of the catalytic core of RRP6 from Trypanosoma brucei, mutant C496S · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q581R8
- Elsewhere: RCSB PDB 4NLC · PDBe 4NLC · UniProt Q581R8
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