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Crystal structure of SUVH9

Analyse Crystal structure of SUVH9 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4NJ5
Type: protein
Length: 482 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Probable histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH9
EC: 2.1.1.43
UniProt: Q9T0G7
Ligands: ZN
Pockets: 6 · best druggability 0.55

Structure

x-ray diffraction · 1 distinct chain · 22% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Probable histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH9 (EC 2.1.1.43)	protein	482	22% helix, 23% strand	Q9T0G7

Ligands and binding sites

ZN · Zinc ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	210	0.55	0.79	37	empty
2	162	0.50	0.78	29	empty
3	104	0.49	0.81	21	empty
4	116	0.49	0.80	20	empty
5	54	0.39	0.81	17	empty

Compared structures

4NJ5 · Crystal structure of SUVH9 · the same entry in another collection · chain A against A, TM-score 1.00
Q9T0G7 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase family member… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9T0G7
Elsewhere: RCSB PDB 4NJ5 · PDBe 4NJ5 · UniProt Q9T0G7

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