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Small molecular fragment bound to crystal contact interface of interleukin-2

Analyse Small molecular fragment bound to crystal contact interface of interleukin-2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4NEM
Type: protein
Length: 114 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Interleukin-2
UniProt: Q6QWN0
Ligands: 2JY
Pockets: 1 · best druggability 0.26

Structure

x-ray diffraction · 1 distinct chain · 63% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Interleukin-2	protein	114	63% helix, 4% strand	Q6QWN0

Ligands and binding sites

2JY · 5-[(2,3-dichlorophenoxy)methyl]furan-2-carboxylic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.26	0.72	15	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

4NEM · Small molecular fragment bound to crystal contact interface of Interleukin-2 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6QWN0
Elsewhere: RCSB PDB 4NEM · PDBe 4NEM · UniProt Q6QWN0

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