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Crystal structure of mycobacterium tuberculosis esx-1 secreted protein regulator (espr)
Analyse Crystal structure of mycobacterium tuberculosis esx-1 secreted protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NDW
- Type
- protein
- Length
- 257 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleoid-associated protein espr
- UniProt
- P96228
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleoid-associated protein espr | protein | 128 | 62% helix, 0% strand | P96228 |
| B | Nucleoid-associated protein espr | protein | 129 | 67% helix, 0% strand | P96228 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 392 | 0.74 | 0.84 | 35 | empty |
| 2 | 212 | 0.50 | 0.76 | 29 | empty |
| 3 | 57 | 0.46 | 0.84 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 2091 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4NDW · Crystal STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS ESX-1 SECRETED PROTEIN REGULATOR (EspR) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P96228
- Elsewhere: RCSB PDB 4NDW · PDBe 4NDW · UniProt P96228
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