Research workbench
IGG1 Fab fragment (MOPC21) complex with domain III of protein G from streptococcus
Analyse IGG1 Fab fragment (MOPC21) complex with domain III of protein G from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1IGC
- Type
- protein
- Length
- 493 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1-kappa MOPC21 Fab (light chain); IGG1-kappa MOPC21 Fab (heavy chain); Streptococcal…
- UniProt
- P01634, P01783, P06654
- Pockets
- 6 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 8% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG1-kappa MOPC21 Fab (light chain) | protein | 213 | 4% helix, 44% strand | P01634 |
| H | IGG1-kappa MOPC21 Fab (heavy chain) | protein | 222 | 7% helix, 50% strand | P01783 |
| A | Streptococcal protein G (domain III) | protein | 58 | 24% helix, 43% strand | P06654 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 585 | 0.61 | 0.73 | 58 | empty |
| 2 | 129 | 0.47 | 0.78 | 27 | empty |
| 3 | 177 | 0.43 | 0.74 | 34 | empty |
| 4 | 67 | 0.38 | 0.79 | 17 | empty |
| 5 | 61 | 0.30 | 0.75 | 18 | empty |
Interfaces
3 interfaces between chains.
- L–H · 2052 Ų buried · 14 hydrogen bonds · protein-protein
- H–A · 604 Ų buried · 17 hydrogen bonds · protein-protein
- L–A · 159 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1IGC · IGG1 Fab fragment (MOPC21) complex with domain III of protein G from streptococcus · the same entry in another collection · chain L against L, TM-score 1.00
- P06654 · AlphaFold monomer V2.0 prediction for immunoglobulin G-binding protein G (P06654) · a predicted model of the same protein · chain A against A, TM-score 0.94
- P01634 · AlphaFold monomer V2.0 prediction for ig kappa chain V-V region mopc 21 (P01634) · a predicted model of the same protein · chain L against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01634
- Every structure of UniProt P01783
- Every structure of UniProt P06654
- Elsewhere: RCSB PDB 1IGC · PDBe 1IGC · UniProt P01634 · UniProt P01783 · UniProt P06654
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.