Research workbench
Crystal structure of photoreceptor ATUVR8 mutant W285F and light- induced structural changes at 120K
Analyse Crystal structure of photoreceptor ATUVR8 mutant W285F and light- induced… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4NC4
- Type
- protein
- Length
- 1,476 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ultraviolet-B receptor UVR8
- UniProt
- Q9FN03
- Ligands
- MG
- Pockets
- 11 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Ultraviolet-B receptor UVR8 | protein | 369 | 6% helix, 44% strand | Q9FN03 |
Ligands and binding sites
- MG · Magnesium ion · metal · 18 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.83 | 0.90 | 63 | MG |
| 2 | 498 | 0.83 | 0.90 | 69 | MG |
| 3 | 492 | 0.76 | 0.84 | 47 | MG |
| 4 | 527 | 0.76 | 0.84 | 46 | empty |
| 5 | 489 | 0.75 | 0.84 | 46 | MG |
Interfaces
5 interfaces between chains.
- A–B · 1449 Ų buried · 37 hydrogen bonds · protein-protein
- C–D · 1444 Ų buried · 38 hydrogen bonds · protein-protein
- A–C · 294 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 23 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 16 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4NC4 · Crystal structure of photoreceptor AtUVR8 mutant W285F and light-induced structural… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9FN03 · AlphaFold monomer V2.0 prediction for ultraviolet-B receptor UVR8 (Q9FN03) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9FN03
- Elsewhere: RCSB PDB 4NC4 · PDBe 4NC4 · UniProt Q9FN03
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