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Probing the N-terminal beta-sheet conversion in the crystal structure of the human prion protein bound to a nanobody
Analyse Probing the N-terminal beta-sheet conversion in the crystal structure of the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N9O
- Type
- protein
- Length
- 231 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major prion protein; Nanobody NB484
- UniProt
- P04156
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major prion protein | protein | 107 | 58% helix, 11% strand | P04156 |
| B | Nanobody NB484 | protein | 124 | 7% helix, 46% strand | — |
Interfaces
1 interface between chains.
- A–B · 667 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4N9O · Probing the N-terminal beta-sheet conversion in the crystal structure of the human prion… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04156
- Elsewhere: RCSB PDB 4N9O · PDBe 4N9O · UniProt P04156
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