Research workbench
Alternative substrates of mycobacterium tuberculosis anthranilate phosphoribosyl transferase
Analyse Alternative substrates of mycobacterium tuberculosis anthranilate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4N93
- Type
- protein
- Length
- 692 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase
- EC
- 2.4.2.18
- UniProt
- P66992
- Ligands
- 6M1, PRP, MG
- Pockets
- 6 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Anthranilate phosphoribosyltransferase (EC 2.4.2.18) | protein | 346 | 51% helix, 12% strand | P66992 |
Ligands and binding sites
- 6M1 · 2-amino-6-methylbenzoic acid · ligand · 4 copies · chains A, B
- PRP · 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 4 copies · chains A, B
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 469 | 0.78 | 0.86 | 53 | MG, 6M1, PRP |
| 2 | 461 | 0.76 | 0.85 | 52 | PRP, 6M1, MG |
| 3 | 61 | 0.45 | 0.83 | 17 | empty |
| 4 | 53 | 0.36 | 0.80 | 15 | empty |
| 5 | 88 | 0.34 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 872 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4N93 · Alternative substrates of Mycobacterium tuberculosis anthranilate phosphoribosyl… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P66992
- Elsewhere: RCSB PDB 4N93 · PDBe 4N93 · UniProt P66992
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